Study

Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR

c7515074-b34a-11eb-9969-acde48001122

Understanding the influence of genetic variants on DNA methylation is fundamental for the interpretation of epigenomic data in the context of disease. The dataset developed in this project provides matched genotyping and DNA methylation data in four tissues (ileum, rectum, T-cells, B-cells) from healthy individuals. Using this data, we demonstrate the discrimination of common from cell-type-specific methQTLs. Our analysis demonstrates that a systematic analysis of methQTLs provides important new insights on the influences of genetic variants to cell-type-specific epigenomic variation.

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Datasets

2
  1. CEDAR EPIC
  2. CEDAR 450K

Study description
Primary purpose
Identification of methylation quantitative trait loci
Description of cohorts
Healthy Individuals

Subjects
Organisms
Homo sapiens
Number of subjects
345
Sample sources
tissue sample
Samples collected
blood rectum ileum CD19+ B-cells CD4+ T-cells CD14+ monocytes transverse colon

Demographic and participant information
Cohort characteristics
BMI 15.94-42.72
age at enrollment 17-86 year