Study

AIMS LEAP Timepoint 1 (T1) and Timepoint 2 (T2)

ELU-4-4D20BB-1

The Longitudinal European Autism Project (LEAP) is currently the largest study in the world to identify variability in autism in terms of behaviour, cognition, co-occurring conditions, outcomes, brain structure/function and genetics. AIMS-LEAP participants have been followed up longitudinally over time, with the current dataset including Timepoint 1 and Timepoint 2 (approx. 12-24-months apart).

Export as DATS
Types Clinical Trial Ncit:c71104

Datasets

9
  1. Longitudinal European Autism Project (LEAP) - DTI - Time point 1 & 2
  2. Longitudinal European Autism Project (LEAP) - Resting-state fMRI - Timepoint 1 (and 2)
  3. Longitudinal European Autism Project (LEAP) - Task based fMRI - Timepoint 1 (and 2)
  4. Longitudinal European Autism Project (LEAP) - Genetics
  5. Longitudinal European Autism Project (LEAP) - Structural MRI - Time point 1
  6. Longitudinal European Autism Project (LEAP) - Clinical - Time point 1 & 2
  7. Longitudinal European Autism Project (LEAP) - Cognitive - Time point 1 & 2
  8. Longitudinal European Autism Project (LEAP) - Eyes Tracking - Time point 1 & 2
  9. Longitudinal European Autism Project (LEAP) - EEG- Time point 1 & 2

Study description
Primary purpose
Autism Innovative Medicines Studies - Longitudinal European Autism Project (AIMS - LEAP)
Study types
Clinical trial NCIT C71104
Description of cohorts
437 autistic individuals and 300 non-autistic individuals total. Please note that N for individual datasets available here will be lower, and will differ between data modalities, due to participant consent preferences for external sharing and data quality. Total number 734 can vary depending on the study measure and timepoint, as well as participant consent preferences for external data sharing

Subjects
Organisms
Homo sapiens
Number of subjects
737
Sample sources
Clinical Neuroimaging Data derived from blood and saliva samples Cognitive Eye-tracking
Samples collected
Physiological Saliva Whole blood tempus Resting state functional magnetic resonance imaging Eye tracking Task based functional magnetic resonance imaging Cognitive Psychometrics Diffusion Tensor Imaging Whole blood EDTA Electroencephalography Questionnaires Structural magnetic resonance imaging Interviews Blood plasma

Demographic and participant information
Cohort characteristics
age at enrollment 6-35 year
Condition Autism , Intellectual disability , ADHD (co-occurring)